The knee joint is made up of bones, tendons, and ligaments, and is connected to various nerves. The nerves that send pain signals from the knee to the brain are collectively called genicular nerves. A genicular nerve block is a minimally invasive, non-surgical procedure used to diagnose and treat chronic knee pain. It involves injecting a local anesthetic to numb the genicular nerves, which can provide temporary pain relief. If the nerve block is successful, it confirms that the pain signals are traveling through these nerves and indicates that a longer-lasting treatment, like a genicular neurotomy, may be effective.